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©KAUST2022; Xavier Pita

Wired for sustainability

Through artificial intelligence, KAUST scientists shift the paradigm from wet lab to wired lab for a more sustainable manufacturing industry.

Two startling statistics drive the sustainable manufacturing research of Gyorgy Szekely at the Advanced Membranes and Porous Materials Center.

The first is that less than 50 percent of the energy consumed by the chemicals-based manufacturing industry is actually used to make their products. Whether a commodity chemical, a polymer for a mobile phone component or a finely crafted pharmaceutical, most energy expenditure occurs in purifying or isolating the desired molecule from the complex mix that it was produced in. Traditional industrial separation techniques, such as distillation, are heat-driven processes that can consume vast amounts of energy when conducted on an industrial scale.

Szekely’s research is focused on a technology that could slash that energy consumption by 90 percent. Replacing high temperature separations with selective porous membranes – to simply filter out the desired product at ambient temperature – can bring dramatic efficiency gains. “Membrane processes use a fraction of the energy of conventional separation technologies,” Szekely says.

“Membrane processes use a fraction of the energy
of conventional separation technologies”

Converting industry’s energy-hungry heat-driven product separations into highly efficient membrane-based processes is a challenge Szekely first faced as a Ph.D. studying chemical engineering, specializing in pharmaceutical separations. “I was part of a European program that brought together industrial and academic partners to try to deal with the product separation problems the industry was facing.” His work has remained focused on industry problems, and some of his membrane separation projects are now in commercial use.

But it’s a slow process. Optimizing separation materials for a particular application involves simultaneously fine-tuning multiple material parameters; traditionally this has meant months of experiments in the lab. The cost of that approach is not just measured in time but in resource consumption and waste generation. “Developing new separation materials potentially creates more sustainability issues than it solves,” Szekely says.

“What the field has struggled with for decades is a lack of organized and accessible data,” Szekely explains. The fragmented information generated for each project rarely allows generalized patterns to be discerned; yet these are needed to make accurate predictions for the next separation problem. “The data problem doesn’t allow us to take the next step and run separations much more efficiently.”

Where data challenges have to date proven intractable to the human eye, today new tools are available to look afresh and pick out patterns we cannot see. “Artificial Intelligence is a fancy new approach to tackling data problems,” Szekely says. “In the past, AI needed large datasets — which we did not have — so there was no possibility of using it for separation technology,” he adds. “Now, based on recent advances in computer science, we can apply it to smaller experimental datasets and already do a lot.”

From a few select experiments conducted in the lab, or from small preexisting datasets, machine learning can be applied to help connect the dots to develop or identify the ideal separation material and conditions for the task. “For us to go to the lab and optimize manually would take ages, but if it is computer-based, we can do it in minutes or hours.”

“For us to go to the lab and optimize manually
would take ages, but if it is computer-based,
we can do it in minutes or hours.”

For the membrane separations subfield of organic solvent nanofiltration, the Szekely group recently created an open-access database that anybody can use to help them with a separation problem. “It is not only a database, we also provide a prediction tool based on machine learning algorithms,” he adds. “People can go online, draw in their molecules and then use the database and the AI to get the solution for their separation problem.”

To put the new computational tool to the test, Szekely sought out a collaboration across the campus at KAUST. “I realized that we are not the only group at KAUST with the word ‘sustainability’ in the name,” Szekely says. “Kyle Lauersen runs the Sustainable and Synthetic Biotechnology Group, so I contacted him to chat about what each of us was doing and how we could work together.”

It turned out that Lauersen and his team had engineered algae for the sustainable bio-production of a pharmaceutical product, patchoulol, but had issues with isolating it. To develop a membrane-based process, the team plugged the problem into the Szekely group’s online tool. “The computer predicted that a membrane would retain 100 percent of the patchoulol, and when we tested that membrane, we measured 100 percent patchoulol recovery,” Szekely says. “The AI was 100 percent accurate in a real-world problem.”

Based on that result, Szekely now has a third compelling statistic to drive his sustainable manufacturing research forward.